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POTASSIUM MAGNESIUM HYDROXYCITRATE AT PHYSIOLOGIC LEVELS INFLUENCES VARIOUS METABOLIC PARAMETERS AND INFLAMMATION IN RATS

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Author: Dallas L. Clouatre and Harry G. Preuss

Abstract: Using oral potassium-magnesium hydroxycitrate (KMgHCA) doses comparable to suggested human intake, effects on systolic blood pressure (SBP), glucose-insulin metabolism, inflammatory markers, blood chemistries and carageenan-induced paw edema were examined in rats. Initially, four groups of eight 8- week old male Sprague-Dawley Rats (SD) received diets supplying calories as 30% fats, 50% carbohydrates and 20% proteins. For 8 weeks, test arms received HCA (from KMgHCA) at 14 mg, 28 mg or 84 mg daily. In a second study, two groups of 6 spontaneously hypertensive rats (SHR) consuming normal rat chow mixed with 20% w/w sucrose were examined (Control or 84 mg HCA daily) to expand findings on SBP and glucose-insulin metabolism. In the first study, there were no significant differences in food intake or weight gain. The 28 mg and 84 mg doses significantly lowered SBP. Inalltestgroups,circulatinginsulinlevelswerelower,but without significance due to variances in Control. The highest test dose significantly reduced paw edema and all doses strongly trended towards reduced CRP and TNF-alpha. There was no evidence of toxicity. In the second study, the intake of KMgHCA (84 mg daily) in genetically hypertensive rats quickly caused a significant decrease in SBP. Losartan challenge suggested the renin-angiotensin system was involved. Glucose tolerance and insulin challenges indicated that KMgHCA enhanced insulin sensitivity.

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Keywords: Blood Pressure, Garcinia Cambogia, (-)- Hydroxycitrate, Inflammation, Insulin, Liver

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