A Broad Overview of the Multifaceted Royal Jelly and Its Applicability in Health and Performance

Royal Jelly (RJ) is a secretion of the hypopharyngeal and mandibular glands of worker bees, and is the exclusive food of the queen bee during her larval stage, so that she reaches almost twice the size of the worker bee. Over the years, the use of RJ has been associated with longevity and improved health quality during aging, post-menopausal hormonal modulation, as an adjuvant in the treatment of Chronic Non-Communicable Diseases, different types of cancer, in dermatology, as an antimicrobial treatment, to enhance fertility, as a nephroprotector, neuroprotector, hepatoprotector, immunometabolism modulator, and cognitive improvement. Only at the beginning of the 21st century did research with RJ and exercise emerge, identifying anti-fatigue effects, decreased serum lactate and ammonia, reduced muscle glycogen depletion, improved athletic performance, attenuating oxidative stress induced by High Intensity Interval Exercise (HIIE), to interrupt neurodegeneration in multiple sclerosis, in the positive modulation of cannabinoid-1 receptors as therapeutic targets for the treatment of autoimmune diseases such as multiple sclerosis, for reducing sarcopenia, skeletal muscle loss and weakness, and inducing mitochondrial adaptation with resistance training by activating AMPK in muscles.

Keywords : Nutraceuticals; oxidative stress; text mining; immunometabolism;